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CHERG - Child Epidemiology Reference Group
Child Mortality and Morbidity
Underlying causes of child death
Effect of co-morbidity on child mortality
Country-level causes of child mortality
Failures in the “pathways to survival”
Incidence and sequelae of child morbidity
Maternal Mortality and Morbidity
Causes of maternal mortality
Incidence and sequelae of maternal morbidity
Risk Factors
Indoor and outdoor air pollution
IUGR and preterm birth as risk factors for morbidity/mortality
Micronutrient deficiencies and nutritional status
Birth spacing as a risk factor of maternal and child mortality
Program-related Evidence
Intervention effectiveness to reduce maternal/child mortality
Measurement of intervention coverage
Enhance the LiST methodology


Intervention effectiveness to reduce maternal/child mortality

As part of the current CHERG, working groups have been formed to do systematic reviews of effectiveness and efficacy of various maternal and child health interventions. These groups are building on reviews that were done for previous work that appeared in the Lancet Series on Child Survival, Neonatal Survival and Maternal and Child Undernutrition.  The reviews of effectiveness in those series, while very good, did not necessarily use a consistent approach to either the reviews of data or in the establishment of best estimates of effectiveness. One purpose of the new review process in CHERG is to ensure that estimates of effectiveness and efficacy for various interventions use comparable methods that will produce comparable outputs which will be published.

A second area of work for CHERG is to investigate the effectiveness of new interventions that were not included in the initial reviews. This could include the effectiveness of new vaccines, such a rotavirus vaccine, or areas that were treated at a more macro level in previous reviews, such as improved sanitation, by refining the estimates of effectiveness to more program-specific interventions. Other areas of work that future reviews of effectiveness will have to address include; 1) the interactions of interventions; estimates of effectiveness of the actual implementation strategy for an intervention; and 3) the cost of interventions and packages of interventions.

Methods and Expected Products

During the two years of the sub-grant, the activities will be focused on analyzing and synthesizing cost data, the indirect effects of interventions on mortality and the interaction of interventions, to ensure that new technologies and program delivery approaches be included in decision-support tools like LiST. Full analysis and specification of how to include these factors within the LiST tool will be made publicly available via the CHERG website and other channels including peer-review.

As part of the review process, activities will include the formation of expert groups to conduct literature reviews and analysis concerning new interventions proposed for inclusion in LiST, as well as to evaluate new data on effectiveness of old interventions to be incorporated into new estimates of effectiveness.  There will be several small-group meetings held durig the two-year sub-grant period, with additional teleconferences.

Related Publications

Eisele TP, Larsen DA, Anglewicz PA, Keating J, Yukich J, Bennett A, Hutchinson P, Steketee RW. Malaria prevention in pregnancy, birthweight, and neonatal mortality: a meta-analysis of 32 national cross-sectional datasets in Africa. Lancet Infect Dis. 2012 Sep 17. pii: S1473-3099(12)70222-0. doi: 10.1016/S1473-3099(12)70222-0. [Epub ahead of print]

Eisele TP, Larsen DA, Walker N, Cibulskis RE, Yukich JO, Zikusooka CM, Steketee RW. Estimates of child deaths prevented from malaria prevention scale-up in Africa 2001-2010. Malar J. 2012 Mar 28;11:93.

Untitled Document

Examination of Child in Benin

PowerPoint Presentation
Global Child Mortality: Estimates of Levels and Causes for 2000-2010

New Publications 
Born Too Small: National and regional estimates of babies born small for gestational age. Healthy Newborn Network Blog on new article in Lancet Global Health

PLOS Med Collection: Measuring Coverage in Maternal, Newborn, and Child Health

LiST Tool
Download the the Lives Saved Tool

Lives Saved Tool in 2013: BMC Public Health Special Issue