CHERG - Child Epidemiology Reference Group
Projects
Child Mortality and Morbidity
Underlying causes of child death
Effect of co-morbidity on child mortality
Country-level causes of child mortality
Failures in the “pathways to survival”
Incidence and sequelae of child morbidity
 
Maternal Mortality and Morbidity
Causes of maternal mortality
Incidence and sequelae of maternal morbidity
 
Risk Factors
Indoor and outdoor air pollution
IUGR and preterm birth as risk factors for morbidity/mortality
Micronutrient deficiencies and nutritional status
Birth spacing as a risk factor of maternal and child mortality
 
Program-related Evidence
Intervention effectiveness to reduce maternal/child mortality
Measurement of intervention coverage
Enhance the LiST methodology

Estimated numbers of deaths by cause in children younger than 5 years by WHO region and country
Table 2 Estimated numbers of deaths by cause

Global, regional, and national causes of child mortality in 2008: a systematic analysis. (2010). The Lancet, 375 (9730): 1969-1987.

Powerpoint Presentation
Global Child Mortality: Status in 2008

Projects

Underlying causes of child death 
Currently, CHERG is working with WHO and UNICEF to develop methodologies and processes to estimate and publish annually the total burden of childhood mortality and causes of death, with first results available in 2009 for the year 2008 and published in 2010. These estimates will include, where the data permit, specific etiologies of diarrhea (e.g. rotavirus) and respiratory disease/meningitis (e.g.  pneumococcus or  H. influenzae type b.)

To date, CHERG has been able to produce one set of cause-specific mortality estimates for the year 2000 and the resulting distribution of causes has been replicated yearly, with very minor adjustments. This project will develop methods/models that allow for annual updates of under-five causes of death by incorporating information on effects of accelerated child survival interventions, such as accelerated coverage of vaccines, use of bednets, introduction of new vaccines (e.g. Hib, Rotavirus, etc), strengthening of community case management of pneumonia, expansion of newborn care interventions, etc.  A second step will involve the validation of the model outputs, requiring strong collaboration with specific programs implementing or scaling-up these interventions in one or two countries.   

Methods and Expected Products 
Epidemiologists, disease experts and statisticians/modelers make up several working groups that are systematically reviewing epidemiologic studies and other sources of data that have collected information on causes of under-five death. Working groups for diarrhea, pneumonia, malaria, and neonatal causes will identify, review, abstract, and analyze all relevant information, and make the information publicly available and disseminated through various channels. CHERG will work with WHO and UNICEF to publish national estimates of child causes of death for all countries beginning with 2008 and continuing annually.

Related Publications
Neonatal Mortality Levels for 193 Countries in 2009 with Trends since 1990: A Systematic Analysis of Progress, Projections, and Priorities. Oestergaard MZ, Inoue M, Yoshida S, Mahanani WR, Gore FM, et al. (2011) PLoS Med 8(8): e1001080. doi:10.1371/journal.pmed.1001080

Stillbirths: Where? When? Why? How to make the data count? Lawn, Joy E, Hannah Blencowe, Robert Pattinson, Simon Cousens, Rajesh Kumar, Ibinabo Ibiebele, Jason Gardosi, Louise T Day, Cynthia Stanton (2011). Lancet. 23; 377(9775): 1448-63.

National, regional, and worldwide estimates of stillbirth rates in 2009 with trends since 1995: a systematic analysis. Cousens, Simon, Hannah Blencowe, Cynthia Stanton, Doris Chou, Saifuddin Ahmed, Laura Steinhardt, Andreea A Creanga, Özge Tunçalp, Zohra Patel Balsara, Shivam Gupta, Lale Say, Joy E Lawn (2011). Lancet. 377(9774): 1319-30.

3.6 million neonatal deaths – what is progressing and what is not?  Lawn, Joy E, Kate Kerber, Christabel Enweronu-Laryea, Simon Cousens (2010). Semin Perinatol. 34(6): 371-86.

Estimating the distribution of causes of child deaths in high mortality counties with incomplete death certification. Johnson, Hope L, Li Liu, Christa L Fischer Walker, Robert E Black (2010).  Int J Epidemiol. 39(4): 1103-14.

Global, regional, and national causes of child mortality in 2008: a systematic analysis.The Lancet (online), 12 May 2010. Robert E Black, Simon Cousens, Hope L Johnson, Joy E Lawn, Igor Rudan, Diego G Bassani, Prabhat Jha, Harry Campbell, Christa Fischer Walker, Richard Cibulskis, Thomas Eisele, Li Liu, Colin Mathers, for the Child Health Epidemiology Reference Group of WHO and UNICEF.

Estimating the distribution of causes of death among children age 1–59 months in high-mortality countries with incomplete death certification. Hope L Johnson, Li Liu, Christa Fischer-Walker and Robert E Black International Journal of Epidemiology, Advanced Access: doi:10.1093/ije/dyq074.

PowerPoint Presentations
Global Child Mortality—Status in 2008

Pathogen Specific Diarrheal Diseases

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