Incidence and sequelae of child morbidity

CHERG will provide estimates of child morbidity, including etiology-specific morbidity, by continuously updating systematic reviews and by seeking additional sources of data from country-level work and from research underway, such as the studies of the etiology of diarrhea and pneumonia funded by The Bill and Melinda Gates Foundation and GAVI.  Incorporating data from these more recent data collection efforts will provide up-to-date estimates and enable the working groups to incorporate the effects of disease-specific child survival interventions into estimates. The data from the selected sites for etiology work must be utilized in a way that allows generalization within and possibly across regions, as sites are not necessarily representative.

Methods and Expected Products

This activity will be carried out by the CHERG morbidity working groups (one each on diarrhea, pneumonia and malaria morbidities) that will conduct systematic reviews of information on child morbidity. The work of the morbidity working groups includes: 

  • identification of on-going projects with active data collection that will be able to contribute up-to-date data on incidence and prevalence of major childhood morbidities;
  • identification of disease specific and comprehensive child survival projects whose accelerated roll-out strategies will affect yearly morbidity estimates;
  • development of a strategy for incorporating data from new large-scale data collection efforts, and relate all data to the changing face of child survival in light of accelerated programs;  
  • collection of the disease specific data and develop a model to estimate the impact of disease-specific interventions and use this to improve morbidity estimates;  
  • examination of the validity of cross-sectional measures of the prevalence of diseases such as diarrhea and respiratory infections;
  • use of the most recent morbidity data to recommend a new set of indicators for use in large-scale surveys such as DHS; and
  • utilization of all available data to estimate the national, regional, and global burden of childhood morbidity. 

Final analyses of all data sources and the modeling of interventions will be made available on the project website, and disease-specific estimates will be published in a peer-reviewed journal. The CHERG morbidity working groups will work with other organizations to develop sub-regional estimates of child morbidity.

Related Publication

Carneiro I, Roca-Feltrer A, Griffin J, Smith L, Tanner M, Armstrong Schellenber J, Greenwood B, Schellenberg D (2010). Age-Patterns of Malaria Vary with Severity, Transmission Intensity and Seasonality in Sub-Saharan Africa: A Systematic Review and Pooled Analysis. PLoS One: 5(2): e8988.

Edmond, K; Scott, S; Korczak, V; Ward, C; Sanderson, C; Theodoratou, E; Clark, A; Griffiths, U; Rudan, I; Campbell, H. Long term sequelae from childhood pneumonia; systematic review and meta-analysis PLoS ONE, 2012 vol. 7(2) pp. e31239

Fischer Walker C, Lamberti L, Adair L, Guerrant RL, Lescano AG, Martorell R, Pinkerton RC, Black RE. Does Childhood Diarrhea Influence Cognition Beyond the Diarrhea-Stunting Pathway?  PLoS One. 2012. 7(10): e47908.

Lamberti LM, Fischer Walker CL, Black RE. Correction: Systematic review of diarrhea duration and severity in children and adults in low- and middle-income countries. BMC Public Health. 2012 Sep 28;12(1):832. [Epub ahead of print]

Diarrhea incidence in low- and middle-income countries in 1990 and 2010: a systematic review. Fischer Walker CL, Perin J, Aryee MJ, Boschi-Pinto C, Black RE. BMC Public Health. 2012 Mar 21;12:220. doi: 10.1186/1471-2458-12-220.

Systematic review of diarrhea duration and severity in children and adults in low- and middle-income countries. Lamberti LM, Fischer Walker CL, Black RE.  BMC Public Health. 2012 Apr 6;12:276.

Burden of disease caused by otitis media: systematic review and global estimates. Monasta L, Ronfani L, Marchetti F, Montico M, Vecchi Brumatti L, Bavcar A, Grasso D, Barbiero C, Tamburlini G.  PLoS One. 2012;7(4):e36226. Epub 2012 Apr 30. 

National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012 Jun 9;379(9832):2162-72. Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R, Adler A, Vera Garcia C, Rohde S, Say L, Lawn JE.

Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review. Lancet 2012; 379: 445–52. Michael K Mwaniki, Maurine Atieno, Joy E Lawn, Charles R J C Newton

Pathogen Specific Diarrheal Diseases

Julia Kaufmann
Julia is 34 years old and has studied nutritional sciences. She specializes in nutrition, health and fitness. To this end, she passionately analyzes the new trends in nutritional supplements, evaluates them under the strictest regulations and does her best to help other people feel better about life.


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