Sudfeld CR, Navar AM, Halsey NA.Effectiveness of Measles Vaccination and Vitamin A Treatment. Int J Epidemiol. 2010 Apr; 39 (Suppl 1): i48-i55.
Measles Vaccination on Measles Disease and All-cause Mortality
Vitamin A Treatment and Measles-specific Mortality
- Meta-analysis of 6 vitamin A treatment RCTs with measles-specific mortality data [High Quality of Evidence]
- No significant reduction in measles mortality including all doses and frequency of vitamin A treatment [RR 0.63; 95% CI 0.37-1.08], but…
- 62% reduction in measles mortality [RR 0.38; 95% CI 0.18-0.81] with > 2 doses of 200 000 IU for children > 1 year of age and 100 000 IU for infants for treatment of measles.
Intervention Recommendation: STRONG
- Measles vaccine and vitamin A treatment are effective interventions to reduce measles mortality in children.
References from Sudfeld Paper Cited Here
- Cutts FT, Henderson RH, Clements CJ et al. Principles of measles control. Bull World Health Organ 1991; 69:1-7.
- World Health Organization, United Nations Children’s Fund. Measles Mortality Reduction and Regional Elimination Strategic Plan 2001-2005. Geneva, Switzerland: World Health Organization, 2001.
- WHO/UNICEF/IVAGG Task Force. Vitamin A Supplements – A Guide to Their Use in the Treatment and Prevention of Vitamin A Deficiency and Xerophthalmia. Geneva: WHO, 1997.